St. Petersburg
Sun: 10:00 - 17:00
NEXT GENERATION SEQUENCING, NGS
Analysis of embryo genome
Healthy
embryo
transfer
THE PROBABILITY OF PREGNANCY WITH PGD NGS
>74%
STUDY OF CHROMOSOMES
23 PAIRS
RESEARCH ACCURACY
99,99%
The criterion for prescription – increased risk of chromosomal or genetic disease. The goal of PGT-a is to identify embryos without specific genetic pathology (genetic or chromosomal). As a result, the diagnosis significantly increases the chances of pregnancy, reduces the number of non-productive IVF cycles and preserves the health of the woman (due to the decrease in the volume of hormones taken).
Application of methods of advanced analysis of the genome provides a comprehensive prognosis of the implementation of the genetic status at all stages of ontogeny the embryo-fetus-child and is the basis for decision-making about embryo transfer in ART programs.
(UP TO 65% - GENERAL GROUP, 69% - SENIOR REPRODUCTIVE AGE)
Diagnosis (PGD) | Targeted analysis of individual chromosomes or genes – monogenic diseases. | |||
Screening (PGS) | Study of chromosomal abnormalities (number and structure of chromosomes).. | |||
Testing (PGT) | Complex combined analysis - exclusion of individual pathology and accidental disorders. For example, the analysis of translocation and estimation of the number of chromosomes in the analysis of single gene and chromosomes. |
We carry out PGS of embryos and PGD not only for couples who want to get pregnant, but also for donors
Pre-implantation genetic testing can be used for different groups of patients:
THE MOST COMMON METHOD OF EMBRYO SELECTION IS BASED SOLELY ON THEIR MORPHOLOGY – THERE IS NO CORRELATION BETWEEN THE MORPHOLOGICAL AND CHROMOSOMAL STATUS OF THE EMBRYO
THE RISK OF CHROMOSOMAL ABNORMALITIES IS IN ALL EMBRYOS IN ALL FAMILIES - THE FREQUENCY OF CHROMOSOME ABNORMALITIES OF THE EMBRYO INCREASES WITH THE AGE OF THE MOTHER.
ART / IVF - taking into account the biological status of the embryo does not give:
IVF does not reduce the risks of chromosomal abnormalities and monogenic diseases.
IVF as a method of infertility treatment does not make it possible to increase the probability of having a healthy child.
ART / IVF is performed in groups of population, increased and high risks of offspring pathology.
For each embryo it was determined:
327 embryos | trisomy on one chromosome | |||
264 embryos | single chromosome monosomy | |||
159 embryos | multiple aneuploidies | |||
224 embryos | mosaic forms of aneuploidies | |||
98 embryos | multiple - mosaic and full of aneuploidies | |||
111 embryos | microdeletion | |||
562 embryos | no deviations were found (recommended for transfer) |
Classical genetic analysis reveals the changed number of chromosomes and large structural disorders. It cannot be used for embryo cells.