Kornilov

Most intense experience in ART programs in Russia. Annual activities:

~ Over 700 cycles of IVF, IVF-ICSI, AF and SM;

~ Over 150 cycles of AI and ovulation induction;

~ Over 300 cycles of ET after cryopreservation.

There are thousands of children born after ART since 1996. There first ART children are studying in universities.

One of the first successful surrogate maternity programs in Russia (the surrogate mother's pregnancy of 1997). Each month, 10-20 surrogate maternity programs are implemented. Most intense experience in surrogate maternity.

First birth after IVF-ICSI program in 1998.

First birth under the program ECO-ICSI ТЕСА (testicular biopsy) in 1998

First pregnancies after cryopreservation in the ET programs (1997) (88 cycles implemented within a year in the Russian Federation in 1998, - nearly all were done in AVA-PETER)

Pioneer (1999) of limitation of transferred embryos (not more than two) (in the Russian Federation in 1999, 44.3% cases of 4 or more embryos transfer into uterus cavity).

Was the first in the Russian Federation, to apply stimulation in IVF recombinant FSH (1996; Report in Sydney, Australia - 1999).

Was the first to introduce practical selective transfer of only one embryo in Russia (eSET) - 2001. Active supporter and promoter of eSET. The most common practice in Russia in eSET (over 40%). Practice in eSET after implementation of the cryopreservation programs.

First pregnancy in Russia (2000) and the greatest experience in the protocols with GnRH antagonists.

Established and practice the scheme to prevent spontaneous LH peak by antiestrogens (clomiphene citrate) for programs up to see, protocols without PE, PGD with PHS (CGH) (2002). Significant cost reduction in patients programs. Report in Lausanne. The scheme has given rise to "Japanese" and "Shanghai" protocol.

The introduction and spread in Russia trigger GnRH agonists in the protocols with antagonists and antiestrogens for AF, SM etc., Preventing OHSS. Proposed to use only 0.1 mg Triptorelin (world prevalence rate- 0.2). Report in Prague, Paris (2001).

Offered the prevention scheme (almost 100%) of OHSS during stimulation for IVF (2012).

A scheme of HRT (substitutive hormonotherapy) for ET, developed specific methods including vaginal administering of estrogens (2001).

Developed and practice scheme to abolish pregnancy drug support after IVF (2003).

Offered the scheme in AF programs with antiestrogens and trigger of a-GnRH (2002). Intensive practical implementation of AF programs and active participation in creation, promotion of the vitrified donor oocytes bank.

Creation and practical implementation of the scheme to stimulate with GnRH antagonists 2-3 days prior to MC for patients with reduced ovarian reserve ("semi-long protocol" or "semi-long") - 2010.

Established and practiced the scheme of preparation for ET after cryopreservation (+ AF and AE) in the natural cycle (based on only 6-d. application of Utrogestan, reaching the sufficient size of endometrium and follicle in the natural cycle, excluding the ovulation time) - 2011.

The first pregnancy in Russia after Federation (2000) after IVF and PGS (preimplantation genetic screening).

The first pregnancy in Russia after PGS with a complete chromosome screening (CCS) of embryos - aCGH (2012). Developed the optimal scheme to stimulate and the scheme of preparation for deferred ET for PGS programs - complete chromosome screening.

Developed and implemented the programs of oocytes "banking" and embryos for highly-reduced ovarian reserve and CCS in 2013.

Development of the PGS-CCS programs without application of IVF, since 2014.

One of the first in world and first in postsoviet countries implemented NGS for PGT-A (2015)

Most intensive IVM experience in world and one of the first pregnancy in world IVM for resistant ovary (2017))

Developed and implemented the programs with niPGT-A(2020)

Developed and implemented the oncofertylity programs in St.Petersburg 2017-2022

Create the most modern in world and one of the biggest in Russia reproductive and genetic net clinics «NGC» (Next Generation Clinic)

Neonatal and clinical outcomes after transfer of a mosaic embryo identifed by preimplantation genetic testing for aneuploidies

Pavel Yakovlev1,*, Svetlana Vyatkina2, Alex Polyakov3,4, Marina Pavlova2, Victor Volkomorov2, Maksim Yakovlev1, Sergey Filimonov1, Liya Kazaryn1, Asia Aizikovich1, Nikolay Kornilov1,2

RBMO 2022 in press

The live birth in a woman with resistant ovary syndrome after in vitro oocyte maturation and preimplantation genetic testing for aneuploidy.

Kornilov NV, Pavlova MN, Yakovlev PP

J Assist Reprod Genet. 2021 Jun;38(6):1303-1309

MPS-based preconception carrier screening: development, verification and user experience

R Vasilyev, S Viatkina, M Strizhova, N Kornilov…

Human Reproduction, Volume 32, Issue suppl_1, July 2017

Triggering of final oocyte maturationin ant GnRH IVFprotocols: triptorelin 0,1vs hCG A randomized multicenter trial

1. Ossina, K. Yavorovskaya, L. Kusmichev, N. Kornilov …

Human Reproduction, Volume 19, Issue suppl_1, 1 June 2004, Pp 102–105

Salim Daya

Fertil Steril. 2002 Apr;77(4):711-4

The protocol for prvention LH surge in COS oocyte donor cycle by clomiphene vs GnRH analogues: a cpss-over design trial

Kornilov N.V., Shlykova, S., Arhangelskaya I.,  Kornilova J and Ashorn, R.G

Human Reproduction, Volume 16, Issue suppl_1, 1 June 2001, Pp 89–91

Effects of exogenic 17β-oestradiol on IVF outcome                                                             . Kornilov N, S. Shlykova, J.A. Loginova, J.A. Kornilova

Human Reproduction, Volume 14, Issue Suppl_3, June 1999, Page 28

Comparison of four different gonadotropins for ovarian stimulation in IVF treatment. In: 11th World Congress on In vitro Fertilization and Human Reproductive Genetics. Monduzzi, Bologna, Italy, 379–383pp. (1999)

Kornilov N.V., Shlykova, S.A., Loginova, J.A., Tomas, C. and Ashorn, R.G.