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Preimplantation Genetic Testing PGT-A with NGS
PGT-A is an advanced embryo genetic test used during IVF to check all 23 chromosome pairs before embryo transfer. At NGC, PGT-A is performed using NGS technology in an in-house genetic laboratory, supporting embryo selection and helping patients make informed decisions about their fertility treatment.
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Transparent pricing — PGS NGS of 1 embryo from €425 · trophectoderm biopsy from €520
What is PGT-A?
PGT-A, or Preimplantation Genetic Testing for Aneuploidy, is a genetic test performed on embryos created during IVF. It checks whether an embryo has the expected number of chromosomes — 46 chromosomes arranged in 23 pairs. Embryos with missing or extra chromosomes are called aneuploid and may have a lower chance of implantation or a higher risk of miscarriage.
- Done before transfer. PGT-A is carried out before the embryo is transferred, so the result can inform which embryo is considered.
- Tested on the embryo, not the patient. A few cells are gently taken from the embryo itself — the test is not performed on the woman.
- Supports embryo selection. PGT-A helps the team consider embryos for transfer based on their chromosomal status, alongside embryo quality.
- Not a guarantee. PGT-A does not guarantee pregnancy and does not rule out every possible genetic condition.
- Different from other tests. PGT-A is not the same as prenatal testing (done during pregnancy) or carrier screening such as NextGen 21
PGT-A, PGT-M, PGT-SR and PGD: what's the difference?
Several similar-sounding terms describe genetic testing of embryos. They test for different things — here's how they compare, so you know which one applies to your situation.
PGT-A
Checks the number of chromosomes (aneuploidy).
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Looks at all 23 chromosome pairs in the embryo
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Considered for recurrent miscarriage, failed IVF, advanced maternal age or repeated implantation failure
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Does not test for specific single-gene diseases
PGT-M
Checks for a known single-gene disorder.
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Used when a specific family mutation is known
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Examples: cystic fibrosis, Huntington's disease, SMA, thalassemia
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Requires prior genetic information about the family
PGT-SR
Checks for structural chromosomal rearrangements.
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Used when one partner carries a structural rearrangement
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Example: a balanced translocation
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Helps identify embryos with a balanced chromosome set
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Geneticist explains your specific reproductive risk
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Options planning if a shared carrier status is found
A note on older terms:
PGS is an earlier name for what is now usually called PGT-A. PGD was a broader, older term for targeted diagnosis and is today generally replaced by PGT-M or PGT-SR.
Who is PGT-A recommended for?
PGT-A is not needed in every IVF cycle, but it may add value in certain situations. A fertility specialist will confirm whether it's appropriate for you. PGT-A may be considered if:
Age & pregnancy history
- The woman is over 35, when the natural rate of chromosomal errors in eggs rises
- There have been recurrent miscarriages, possibly linked to embryo chromosomes
- There have been repeated failed IVF cycles despite good-quality embryos
Embryo & chromosomal factors
- Previous embryos were found to have chromosomal abnormalities
- One partner carries a chromosomal rearrangement, such as a balanced translocation
- You want to lower the chance of transferring an aneuploid embryo
Treatment goals & donor cycles
- Donor eggs or sperm are used and confident embryo selection matters
- You want to transfer a single embryo with greater confidence
- A fertility specialist or genetic counsellor has recommended embryo testing
PGT-A is not necessary for every IVF patient. The decision should be made after consultation with a fertility specialist, embryologist or genetic counsellor — based on your medical history, age, the number of embryos and your treatment goals.
How PGT-A works in an IVF cycle
Consultation and treatment planning
Your doctor reviews your age, medical history, previous IVF cycles, miscarriages and genetic risks, then explains whether PGT-A is likely to add value in your case.
IVF or ICSI cycle
After ovarian stimulation, eggs are retrieved and fertilised with sperm in the laboratory — by conventional IVF or by ICSI, depending on your situation.
Embryo culture to blastocyst stage
The embryos are cultured for five to six days until they reach the blastocyst stage, when they are developed enough for a safe biopsy.
Trophectoderm biopsy
An embryologist carefully removes a few cells from the trophectoderm — the outer part of the embryo that later forms the placenta, not the baby itself.
Embryo freezing
The embryos are vitrified (frozen) and stored safely while the laboratory carries out the genetic analysis, so nothing is rushed.
NGS chromosome analysis
NGC's in-house genetic laboratory analyses all 23 chromosome pairs using next-generation sequencing, checking each embryo for the expected chromosome number.
Report and interpretation
You receive a report classifying each embryo as euploid, aneuploid, mosaic or requiring discussion. Your doctor explains which embryos may be considered for transfer.
Frozen embryo transfer
Once results are ready, your doctor plans the transfer of a suitable embryo — or, if needed, discusses alternative options with you.
Note: The biopsy is performed by experienced embryologists at the blastocyst stage and is designed to minimise any impact on embryo development.
What can PGT-A results show?
After analysis, each embryo is classified by its chromosomal status. Here's what each result means — and why the final decision always involves your doctor.
Euploid embryo
The embryo has the expected 46 chromosomes in 23 pairs. It may be considered for transfer, taking into account embryo quality, your age and your medical situation.
Aneuploid embryo
The embryo has too few or too many chromosomes. It is usually not recommended for transfer, because of a lower chance of implantation and a higher risk of miscarriage.
Mosaic embryo
The sample shows both normal and abnormal cells. These results need individual discussion with your doctor or geneticist, who will explain whether the embryo could be considered.
No result / inconclusive
Sometimes a clear result cannot be obtained. Your doctor may discuss repeating the analysis, a re-biopsy, or an alternative plan depending on your situation.
PGT-A results should always be interpreted together with embryo morphology, patient age, treatment history and your doctor's recommendation — never on the chromosomal result alone.
Benefits and limitations of PGT-A
PGT-A can be valuable for some patients, but it is not right for everyone and has clear limitations. Understanding both sides helps you make an informed decision with your specialist.
- May help identify embryos with the expected number of chromosomes
- May reduce the chance of transferring an aneuploid embryo
- May reduce the risk of miscarriage in selected patients
- Helps you and your doctor make informed embryo-transfer decisions
- May support single embryo transfer, lowering the chance of twins
- May reduce the number of unsuccessful transfers in some cases
- PGT-A does not guarantee pregnancy
- PGT-A does not guarantee a healthy baby
- PGT-A does not test for all genetic diseases or single-gene disorders
- It may reduce the number of embryos available for transfer
- Prenatal screening or testing may still be recommended during pregnancy
Whether PGT-A is right for you depends on your age, history and number of embryos. Our specialists will talk you through both sides honestly.
Why choose PGT-A at NGC?
In-house genetic laboratory
PGT-A is performed in NGC's own genetic laboratory, not outsourced to a third party. That means tighter quality control and a faster, smoother path from biopsy to result.
NGS technology
Analysis uses next-generation sequencing to assess all 23 chromosome pairs. It's a modern, high-resolution method for checking an embryo's chromosomal status.
2 Illumina MiSeq sequencers
Our laboratory runs on two Illumina MiSeq sequencers — established, clinically trusted platforms for accurate chromosome analysis.
Experienced embryology team
Embryo biopsy is a delicate step. At NGC it is carried out by experienced embryologists, working to protect embryo quality throughout.
Integrated IVF & donor programs
PGT-A connects directly to NGC's IVF, egg donation, sperm donation and embryo donation programs — one coordinated plan rather than separate services.
International patient support
Online consultations, English-language support and help with travel logistics make it practical to plan PGT-A from abroad.
Transparent pricing
Clear prices — PGS NGS of one embryo from €425 and trophectoderm biopsy from €520 — with the final cost confirmed for your treatment plan.
Part of NGC's genetic services
PGT-A sits alongside NextGen 21 carrier screening and other genetic services, so your family's genetic picture is handled in one place.
PGT-A cost and what's included
Transparent PGT-A pricing — the final cost depends on the number of embryos tested and your IVF plan.
PGS NGS of 1 embryo — from €425
Trophectoderm biopsy — from €520
What's included
- Consultation with a fertility specialist
- Embryo biopsy by an experienced embryologist
- NGS analysis of all 23 chromosome pairs
- Laboratory report with your results
- Interpretation of results with your doctor
- Frozen embryo transfer planning
Please confirm what's included: depending on your plan, the consultation, report and interpretation may be part of the price or billed separately. Your coordinator provides a clear breakdown first.
Related IVF and genetic services
PGT-A works best as part of a complete fertility plan. Explore the related services at NGC:
IVF treatment
Full in-vitro fertilisation programs tailored to your diagnosis. PGT-A can be built into the cycle for embryo selection.
ICSI
Fertilisation by injecting a single sperm directly into the egg. Often used together with PGT-A in the same IVF cycle.
Egg donation
Donor egg IVF programs with screened donors. PGT-A adds an extra layer of confidence to embryo selection.
Sperm donation
Programs using screened donor sperm. Can be combined with PGT-A and other genetic testing for added reassurance.
Embryo donation
Programs using donated embryos for patients who need them. Your coordinator explains how genetic testing applies.
Guarantee packages
Shared-risk and refund programs that combine IVF with genetic testing for greater certainty over your treatment.
NextGen 21
Carrier screening that checks parents for 18 inherited diseases — a natural companion to PGT-A before pregnancy.
Embryological laboratory
NGC's in-house embryology lab, where biopsy and culture are performed under tightly controlled conditions.
Ri Witness
An electronic witnessing system that tracks every sample, adding a layer of safety throughout your IVF cycle.
Time-lapse system
Continuous embryo monitoring in a stable incubator, supporting better selection without disturbing development.
Travel support
Help with scheduling, logistics and English-language coordination, so international patients can plan with ease.
Free consultation
Discuss your case with our specialists at no cost — including whether PGT-A may be suitable for you.
Frequently Asked Questions
What is PGT-A?
PGT-A (Preimplantation Genetic Testing for Aneuploidy) is a genetic test performed on embryos during IVF. It checks whether an embryo has the expected number of chromosomes — 46 in 23 pairs — to support embryo selection before transfer.
Is PGT-A the same as PGS?
Essentially yes. PGS (Preimplantation Genetic Screening) is the older name for what is now called PGT-A. The technology has advanced, but the goal — checking the chromosome number of embryos — is the same.
What's the difference between PGT-A, PGT-M and PGT-SR?
PGT-A checks the number of chromosomes. PGT-M tests for a known single-gene disorder in the family. PGT-SR is used when a partner carries a structural chromosomal rearrangement, such as a balanced translocation.
How many chromosomes does PGT-A test?
PGT-A examines all 23 pairs of chromosomes — 46 in total — checking whether the embryo has the expected number, with no missing or extra chromosomes.
Who should consider PGT-A?
PGT-A may be considered for women over 35, after recurrent miscarriages or failed IVF cycles, when a partner has a chromosomal rearrangement, or when confident embryo selection matters. A specialist decides if it's appropriate for you.
Is PGT-A recommended for women over 35?
It may be, because the natural rate of chromosomal errors in eggs rises with age. However, age alone doesn't decide it — your specialist weighs your full history and number of embryos before recommending PGT-A.
Can PGT-A help after failed IVF cycles?
For some patients, yes. After repeated failed transfers, PGT-A may help identify embryos with the expected chromosome number. Its benefit varies between patients and should be discussed with your fertility specialist.
Can PGT-A reduce miscarriage risk?
In selected patients, PGT-A may reduce the chance of miscarriage linked to chromosomal abnormalities, by avoiding the transfer of aneuploid embryos. It cannot prevent miscarriage from other causes.
Does PGT-A guarantee pregnancy?
No. PGT-A can support embryo selection, but it does not guarantee pregnancy. Success still depends on many factors, including embryo quality, the uterus and your overall medical situation.
Does PGT-A guarantee a healthy baby?
No. PGT-A checks chromosome number only. It does not test for all genetic conditions or single-gene diseases, so it cannot guarantee a healthy baby. Prenatal care is still recommended.
Can PGT-A detect single-gene diseases?
No. PGT-A checks chromosome number only. To test for a specific inherited single-gene disorder, a different test — PGT-M — is used, when a known family mutation exists.
Do I still need prenatal testing after PGT-A?
Possibly. PGT-A reduces but does not remove the need for prenatal care. Your doctor may still recommend prenatal screening or testing during pregnancy, depending on your situation.
Is embryo biopsy safe?
Embryo biopsy is a well-established procedure performed by experienced embryologists at the blastocyst stage. It is designed to minimise any impact on embryo development. (формулировку безопасности подтвердить у NGC)
When is embryo biopsy performed?
The biopsy is usually performed at the blastocyst stage, around day 5–6 of embryo development, when a few cells can be taken from the trophectoderm (the part that later forms the placenta).
How long does it take to get PGT-A results?
Turnaround depends on the laboratory schedule and number of embryos. Your coordinator will give you an expected timeframe for your cycle. (точный срок подтвердить у NGC)
What does euploid mean?
A euploid embryo has the expected number of chromosomes (46 in 23 pairs). It may be considered for transfer, taking into account embryo quality, your age and your medical situation.
What does aneuploid mean?
An aneuploid embryo has missing or extra chromosomes. It is usually not recommended for transfer because of a lower chance of implantation and a higher risk of miscarriage.
What does mosaic embryo mean?
A mosaic embryo shows a mix of normal and abnormal cells. These results need individual discussion with your doctor or geneticist, who will explain whether the embryo could be considered.
How much does PGT-A cost at NGC?
At NGC, PGS NGS of one embryo starts from €425 and trophectoderm biopsy from €520. The final cost depends on the number of embryos tested and your IVF plan. (цены подтвердить у NGC)
Can international patients do IVF with PGT-A at NGC?
Yes. NGC supports international patients with online consultations, English-language coordination and help with travel logistics, so you can plan IVF with PGT-A from abroad.
Ready to discuss IVF with PGT-A?
Our international team can review your medical history, explain whether PGT-A may be suitable for your case, and prepare an individual IVF treatment plan — at no cost and with no obligation.
